Cryo-EM Nanovises

The end of orientation bias.

In traditional cryo-EM, the most significant hurdles aren't the microscope—they are the grid. Between "preferred orientation" bias, particle aggregation at the air-water interface, and the 20nm "cloud of uncertainty" in localization, researchers spend more time troubleshooting samples than solving structures.

NanoVises change the game. By combining rigid, asymmetric DNA nanotechnology with high-affinity RNA aptamers, we provide a mechanical "anchor" for your proteins, ensuring they are perfectly positioned for high-resolution reconstruction.

Precision Orientation & Placement: Eliminate anisotropic bias. NanoVises act as molecular scaffolds that hold proteins in non-overlapping, evenly spaced, and controlled orientations.

Zero "Cloud of Uncertainty": Unlike flexible antibodies, our rigid 90nm asymmetric structure defines the exact 3D pose of your target, allowing you to trace the signal directly to the protein.

A Seamless "Drop-In" Solution

NanoVises are designed to simplify your workflow, not complicate it.

Universal Compatibility: Functionalize with any standard fluorescent tag (GFP, YFP, ATTO) or specific markers dependent on your needs.

Controlled Ice Thickness: Our system helps achieve a defined ice layer (approx. 30nm) under reliable freezing conditions, ensuring consistent data across the entire grid.

High-Density Data: By solving particle yield and orientation issues, NanoVises enable faster time-to-insight and more reliable sub-volume averaging.