PRODUCTS AND SERVICES

Custom nano-engineering projects

Whether you already have an exact shape in mind, or are interested in how to best implement a novel functionality in your system, our team will help you make your vision reality. We afterwards help you scale up production to meet demands.

 

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Why order with us?

  • Constant Exchange

    Our team of scientists will maintain consistent communication with you throughout the project's duration. This collaborative approach ensures your active involvement in the development process, allowing us to work together to create a product that optimally meets your specific requirements.

  • 10+ years expertise

    Our comprehensive experience in DNA origami enables us to design and synthesize highly optimized nanostructures with efficient assembly kinetics and enhanced thermodynamic stability. Our portfolio encompasses a wide range of architectures, from planar 2D arrays to complex 3D conformations and higher-order multimeric assemblies. This extensive body of work has provided us with in-depth insights into both the capabilities and constraints of DNA origami technology.

  • Scale up Help

    You have a first Proof of Principle and need to scale up workflows, or have lab SOPs that need to enter high volume production? We have the infrastructure and know-how to produce your DNA origami designs in high volume and quality.

    We optimize the assembly of your nanostructure with our in-house experts before moving into production.

We help make your vision a reality with DNA origami and years of experience

Whether you’re just starting to explore the potential of DNA origami or already have a clear vision for a project that needs execution power, our team is here to guide you from concept to reality.

We make it our priority to ensure that our DNA origami products are tailored to fit your specific system. Our experts work with you directly, offering clear and transparent communication throughout the process. We’re committed to being your partner from start to finish.

You’ll receive ready-to-use DNA origami structures, formulated to work seamlessly within your application. And when your project succeeds, we’re here to help you scale up production to meet growing demands, continuing to evolve with you as your trusted partner for long-term success.

With our experience and cutting-edge products, we are ready to help turn your vision into reality.

Application Areas

Application Areas

At tilibit nanosystems, we have broad expertise in designing custom DNA structures tailored to the specific needs of our customers. We enable researchers to unlock the full potential of DNA origami across a wide range of applications.

The versatility of DNA origami stems from its ability to generate highly uniform nanostructures with precise molecular positioning capabilities. This technique also allows for the incorporation of dynamic elements such as molecular motors or conformational switches at the nanoscale level.

Moreover, DNA origami structures exhibit remarkable stability post-assembly while being composed of biodegradable biopolymers. This unique combination of properties positions DNA origami as a promising sustainable alternative for various nanoscale applications in fields ranging from biomedical engineering to materials science.

Our collaborative projects span a wide range of scientific disciplines:

Molecular diagnostics and drug development

  • We can create tunable ultra-bright molecular probes with many dyes and customized recognition sites, whether using ssDNA, RNA, or antibodies. These probes have improved specificity and signal strength, and can be used for a wide range of spatial, single-cell, and in-situ labelling applications.[MOU1] 
  • We can create biochips with improved site densities and reduced production costs, for high-throughput and low-cost DNA sequencing and proteomics applications, using the molecular placement capabilities of our nanostructures. (www.nanogami.bio)

We can create molecular probes for protein cryoEM applications, such as :

 

Proteomics

Molecular tools for studying proteins and other biomolecules in solid-state nanopores, such as

Single molecule sensing

We can generate nanostructure markers with defined numbers of fluorescent dyes and binding sites, in fixed 3-dimensional arrangements, to be used as standards for regular and super-resolution microscopy. We can also generate custom designs where individual molecules are placed with extremely high precision for cutting-edge technology development and validation.

 

Surface patterning

The nanometer-scale features of our nanostructures can be transferred onto surfaces such as semiconductor materials through lithographic processes. This may open a route towards next generation semiconductor device production.

  1. DNA Origami for Silicon Patterning
  2. DNA Origami Mask for Sub-Ten-Nanometer Lithography

 

Drug delivery

Cargo molecules can be encapsulated within a nanostructure and released in a target environment or upon receiving an external signal. Due to the molecular programmability of the structures we can design shape-recognition or allosteric mechanisms and release the cargo upon binding to the target.

 

And many other diverse fields, such as