Single-molecule microscopy

Single-molecule measurements need both separable targets and a reliable spatial reference. The tiliGRID family brings defined molecular patterns to microscopy surfaces, helping you prepare samples and check what your imaging system resolves.

Calibrate in three dimensions

tiliGRID-Z places DNA-PAINT docking sites at defined heights on surface-bound L-shaped nanostructures. Use the reference geometry to evaluate axial localization, compare imaging conditions and check your analysis before measuring an unknown sample.

Place the molecules you want to study

tiliGRID Biotin supplies patterned attachment sites on an anti-fouling surface. The local four-site arrangement supports controlled target placement for localization and colocalization experiments, with less reliance on random immobilization.

Assemble an experiment around a pattern

Custom tiliGRID can combine distinct capture handles for molecular interaction studies or your own imaging references. Choose calibration, molecule placement or a custom configuration from the same family. Explore surface-placement development for other substrates and nanowells.