Research references
Published research using tilibit nanostructures and assembly materials. Explore the experiments grouped by application on our custom DNA designs page.
Research using complete nanostructures supplied by tilibit
Mazal et al. (2025). Cryogenic light microscopy of vitrified samples with angstrom precision.
Al-Zarah et al. (2025; published online 2024). A versatile approach for geometry-based self-assembly of DNA–protein hybrid nanostructures using histone–DNA interactions.
Ray et al. (2024). DNA origami: thinking ‘outside the fold’ for direct integrity testing of membranes for virus removal in potable reuse applications.
Yu et al. (2024). Nanopatterned Monolayers of Bioinspired, Sequence-Defined Polypeptoid Brushes for Semiconductor/Bio Interfaces.
Joseph et al. (2023). Biodistribution and function of coupled polymer-DNA origami nanostructures.
Al-Zarah et al. (2023). Self-Assembly of Geometry-Based DNA Origami–Histone Protein Hybrid Nanostructures for Constructing Rationally-Designed Higher-Order Structures.
Kler et al. (2022). Packaging of DNA origami in viral capsids: towards synthetic viruses.
Schmid et al. (2021). Nanopore electro-osmotic trap for the label-free study of single proteins and their conformations.
Böning et al. (2021; published online 2020). Polarization-Encoded Colocalization Microscopy at Cryogenic Temperatures.
Thomas et al. (2020). DNA Origami for Silicon Patterning.
Kopatz et al. (2019). Packaging of DNA origami in viral capsids.
Diagne et al. (2016). DNA Origami Mask for Sub-Ten-Nanometer Lithography.
Doctoral research
White (2020). Single-Molecule Studies of Ligand Binding to Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion Channels in Zero-Mode Waveguides. Doctoral dissertation, University of Wisconsin–Madison. Includes custom tilibit PF-6 sheets for loading-and-release development.
Research using tilibit scaffold DNA and folding materials
These studies use tilibit materials within structures assembled by the researchers. They are distinct from the complete-structure supplies listed above.
(2025) Hierarchical access to encoded data on DNA nanostructures using administrator and user keys.
(2025) DNA Origami Barcodes for Immunostaining.
(2024) The DNA-PAINT palette: a comprehensive performance analysis of fluorescent dyes.
(2023) DNA-origami-directed virus capsid polymorphism.
(2023) Multivalent insulin receptor activation using insulin–DNA origami nanostructures.
(2023) Signal Amplification in Electrochemical DNA Biosensors Using Target-Capturing DNA Origami Tiles.
(2022) Photoswitching fingerprint analysis bypasses the 10-nm resolution barrier.
Shetty, Rothemund, Gopinath, Hariadi, Brady (2021) Bench-Top Fabrication of Single-Molecule Nanoarrays by DNA Origami Placement http://doi.org/10.1021/acsnano.1c01150
Gopinath, Thachuk, Mitskovets, Atwater, Kirkpatrick, Rothemund (2021) Absolute and arbitrary orientation of single molecule shapes http://doi.org/10.1126/science.abd6179
P Williamson, H Ijäs, B Shen, DK Corrigan, V Linko (2021) Probing the conformational states of a pH-sensitive DNA origami zipper via label-free electrochemical methods, Langmuir
AJ Lee, M Endo, JK Hobbs, AG Davies, et al. (2021) Micro-homology intermediates: RecA's transient sampling revealed at the single molecule level, Nucleic Acids Research
H Ijäs, B Shen, A Heuer-Jungemann, et al. (2021) Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release, Nucleic Acids Research
C Lanphere, D Offenbartl-Stiegert, A Dorey, G Pugh, et al. (2021) Design, assembly, and characterization of membrane-spanning DNA nanopores, Nature protocols
L Sala, A Zerolová, A Rodriguez, D Reimitz, et al. (2021) Folding DNA into origami nanostructures enhances resistance to ionizing radiation, Nanoscale
L Xin, X Duan, N Liu (2021) Dimerization and oligomerization of DNA-assembled building blocks for controlled multi-motion in high-order architectures, Nature communications
E Silvester, B Vollmer, V Pražák, D Vasishtan, et al. (2021) DNA origami signposts for identifying proteins on cell membranes by electron cryotomography, Cell
E Benson, R Carrascosa Marzo, J Bath, AJ Turberfield (2021) Strategies for Constructing and Operating DNA Origami Linear Actuators, Small
RML Berger, JM Weck, SM Kempe, O Hill, T Liedl, et al. (2021) Nanoscale FasL Organization on DNA Origami to Decipher Apoptosis Signal Activation in Cells, Small
K Jahnke, N Ritzmann, J Fichtler, A Nitschke, et al. (2021) Proton gradients from light-harvesting E. coli control DNA assemblies for synthetic cells, Nature communications
LS Fischer, C Klingner, T Schlichthaerle, et al. (2021) Quantitative single-protein imaging reveals molecular complex formation of integrin, talin, and kindlin during cell adhesion, Nature communications
K Jahnke, N Ritzmann, J Fichtler, A Nitschke, Y Dreher, et al. (2021) Proton gradients from light-harvesting E. coli control DNA assemblies for synthetic cells, Nature communications
Filius, Cui, Ananth, Docter, Hegge, van der Oost, Joo (2020) High-Speed Super-Resolution Imaging Using Protein-Assisted DNA-PAINT http://doi.org/10.1021/acs.nanolett.9b04277
MK Nguyen, VH Nguyen, AK Natarajan, et al. (2020) Ultrathin silica coating of DNA origami nanostructures, Chemistry of Materials
S Liu, S Murata, I Kawamata (2020) DNA Ring Motif with Flexible Joints, Micromachines
TY Yang, L Yu, Y Akiyama, T Takarada, M Maeda (2020) DNA-Programmed Bimodal 2D Assembly of Differently Sized Nanoparticles via Folding of Precursory Circular Chains, Langmuir
K Göpfrich, MJ Urban, C Frey, I Platzman, JP Spatz, et al. (2020) Dynamic actuation of DNA-assembled plasmonic nanostructures in microfluidic cell-sized compartments, Nano Letters
T Watanabe, Y Sato, H Otaka, I Kawamata, S Murata, et al. (2020) DNA origami “quick” refolding inside of a micron-sized compartment, Molecules
J Ye, R Weichelt, U Kemper, V Gupta, TAF König, et al. (2020) Casting of Gold Nanoparticles with High Aspect Ratios inside DNA Molds, Small
B Zhang, K Martens, L Kneer, T Funck, L Nguyen, et al. (2020) DNA Origami Nano-Sheets and Nano-Rods Alter the Orientational Order in a Lyotropic Chromonic Liquid Crystal, Nanomaterials
P Piskunen, S Nummelin, B Shen, MA Kostiainen, et al. (2020) Increasing complexity in wireframe DNA nanostructures, Molecules
W Fang, M Xie, X Hou, X Liu, X Zuo, et al. (2020) DNA origami radiometers for measuring ultraviolet exposure, Journal of the American Chemical Society
Woods, Doty, Myhrvold, Hui, Zhou, Yin, Winfree (2019) Diverse and robust molecular algorithms using reprogrammable DNA self-assembly, Nature, https://doi.org/10.1038/s41586-019-1014-9
Bartnik, Barth, Pilo-Pais, Crevenna, Liedl, Lamb (2019) A DNA origami platform for single-pair Förster Resonance Energy Transfer investigation of DNA-DNA interactions and ligation. http://doi.org/10.1021/jacs.9b09093
Liu, Weiss, Kuzyk, Duan, Both, Urban, Zhan (2019) DNA-assembled nanoarchitectures with multiple components in regulated and coordinated motion. http://doi.org/10.1126/sciadv.aax6023
Ijäs, , Kostiainen, Linko, Hakaste (2019) Reconfigurable DNA Origami Nanocapsule for pH-Controlled Encapsulation and Display of Cargo http://doi.org/10.1021/acsnano.9b01857
Rödiger, Tinnefeld, Bald, Choi (2019) A new reporter design based on DNA origami nanostructures for quantification of short oligonucleotides using microbeads. http://doi.org/10.25932/publishup-42827
Vogel, Ebel, Schürmann, Heck, Meiling, et al. (2019) Vacuum-UV and low-energy electron induced DNA strand breaks - Influence of the DNA sequence and substrate http://doi.org/10.1002/cphc.201801152
Choi, Tinnefeld, Bald, Rödiger, Schmidt (2019) A new reporter design based on DNA origami nanostructures for quantification of short oligonucleotides using microbeads http://doi.org/10.1038/s41598-019-41136-x
Julin, Korpi, Nonappa, Shen, Liljeström, Ikkala, Keller, Linko, Kostiainen (2019) DNA origami directed 3D nanoparticle superlattice via electrostatic assembly. http://doi.org/10.1039/C8NR09844A
X Jing, F Zhang, M Pan, X Dai, J Li, L Wang, X Liu, et al. (2019) Solidifying framework nucleic acids with silica, Nature protocols
X Xu, S Fang, Y Zhuang, S Wu, Q Pan, L Li, X Wang, et al. (2019) Cationic albumin encapsulated DNA origami for enhanced cellular transfection and stability, Materials
L Xin, C Zhou, X Duan, N Liu (2019) A rotary plasmonic nanoclock, Nature communications
P Zhan, MJ Urban, S Both, X Duan, et al. (2019) DNA-assembled nanoarchitectures with multiple components in regulated and coordinated motion, Science Advances
S Vogel, K Ebel, C Heck, RM Schürmann, et al. (2019) Vacuum-UV induced DNA strand breaks–influence of the radiosensitizers 5-bromouracil and 8-bromoadenine, Physical Chemistry Chemical Physics
T Mino, N Iwai, M Endo, K Inoue, K Akaki, et al. (2019) Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs, Nucleic Acids Research
Y Huang, MK Nguyen, A Kuzyk (2019) Assembly of gold nanorods into chiral plasmonic metamolecules using DNA origami templates, JoVE (Journal of Visualized Experiments)
K Fujita, M Ohmachi, K Ikezaki, T Yanagida, et al. (2019) Direct visualization of human myosin II force generation using DNA origami-based thick filaments, Communications Biology
B Sheheade, M Liber, M Popov, Y Berger, DC Khara, et al. (2019) Self‐Assembly of DNA Origami Heterodimers in High Yields and Analysis of the Involved Mechanisms, Small
F Scheffler, M Brueckner, J Ye, R Seidel, et al. (2019) A Hybrid Carrier System Based on Origami Nanostrucutures and Layer‐by‐Layer Microparticles, Advanced Functional Materials
ME Kizer, RJ Linhardt, AR Chandrasekaran, X Wang (2019) A molecular hero suit for in vitro and in vivo DNA nanostructures, Small
J Valero, M Centola, Y Ma, M Škugor, Z Yu, et al. (2019) Design, assembly, characterization, and operation of double-stranded interlocked DNA nanostructures, Nature protocols
Fritzsche, Csáki, Dathe, Slesiona, Thamm (2018) AFM-Based Probing of the Flexibility and Surface Attachment of Immobilized DNA Origami http://doi.org/10.1021/acs.langmuir.8b02362
Choi, Kotthoff, Olejko, Resch-Genger, Bald (2018) DNA origami-based Förster resonance energy-transfer nanoarrays and their application as ratiometric sensors http://doi.org/10.1021/acsami.8b03585
Kostiainen, Linko, Mikkilä (2018) Packaging DNA origami into viral protein cages http://doi.org/10.1007/978-1-4939-7808-3_18
B Shen, V Linko, JJ Toppari (2018) DNA-assisted molecular lithography, DNA Nanotechnology
Y Choi, L Kotthoff, L Olejko, et al. (2018) DNA origami-based forster resonance energy-transfer nanoarrays and their application as ratiometric sensors, ACS Applied Materials & Interfaces
B Shen, V Linko, K Tapio, S Pikker, et al. (2018) Plasmonic nanostructures through DNA-assisted lithography, Science Advances
R Chikkaraddy, VA Turek, N Kongsuwan, F Benz, et al. (2018) Mapping nanoscale hotspots with single-molecule emitters assembled into plasmonic nanocavities using DNA origami, Nano Letters
F Kollmann, S Ramakrishnan, B Shen, et al. (2018) Superstructure-dependent loading of DNA origami nanostructures with a groove-binding drug, ACS Omega
VA Turek, R Chikkaraddy, S Cormier, et al. (2018) Thermo‐Responsive Actuation of a DNA Origami Flexor, Advanced Functional Materials
T Bayrak, S Helmi, J Ye, D Kauert, J Kelling, et al. (2018) DNA-mold templated assembly of conductive gold nanowires, Nano Letters
MJ Urban, S Both, C Zhou, A Kuzyk, K Lindfors, et al. (2018) Gold nanocrystal-mediated sliding of doublet DNA origami filaments, Nature communications
D Wang, J Song, P Wang, V Pan, Y Zhang, D Cui, et al. (2018) Design and operation of reconfigurable two-dimensional DNA molecular arrays, Nature protocols
Zanacchi, Manzo, Alvarez, Derr, Parajo, Lakadamyali (2017) DNA Origami offers a versatile method for quantifying protein copy‐number in superresolution http://doi.org/10.1038/nmeth.4342
HJ Su, CE Castro, AE Marras, et al. (2017) The Kinematic Principle for Designing Deoxyribose Nucleic Acid Origami Mechanisms: Challenges and Opportunities, Journal of Mechanical Design
FC Zanacchi, C Manzo, AS Alvarez, ND Derr, et al. (2017) A DNA origami platform for quantifying protein copy number in super-resolution, Nature Methods
A Kuzyk, MJ Urban, A Idili, F Ricci, et al. (2017) Selective control of reconfigurable chiral plasmonic metamolecules, Science Advances
V Korpelainen, V Linko, J Seppä, et al. (2017) DNA origami structures as calibration standards for nanometrology, Measurement Science and Technology
T Uchida, K Abe, Y Endo, S Ichiseki, S Akita, S Liu, et al. (2017) Revolving Vernier Mechanism Controls Size of Linear Homomultimer, Small
K Toropova, M Mladenov, AJ Roberts (2017) Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements, Nature structural & molecular biology
L Olejko, I Bald (2017) FRET efficiency and antenna effect in multi-color DNA origami-based light harvesting systems, Rsc Advances
Derr, Driller-Colangelo, Chau, Morgan (2016) Cargo rigidity affects the sensitivity of dynein ensembles to individual motor pausing http://doi.org/10.1002/cm.21339
Keller, Ramakrishnan, Stewart, Grundmeier (2016) Regular Nanoscale Protein Patterns via Directed Adsorption through Self-Assembled DNA Origami Masks http://doi.org/10.1021/acsami.6b10535
Kostiainen, Kiviaho, Linko, Ora, Tiainen, Järvihaavisto, Mikkilä, Tenhu, Nonappa (2016) Cationic polymers for DNA origami coating – examining their binding efficiency and tuning the enzymatic reaction rates http://doi.org/10.1039/C5NR08355A
Keller, Schlierf (2016) Structural stability of DNA origami nanostructures in the presence of chaotropic agents http://doi.org/10.1039/c6nr00835f
Kuzyk, Liu, Yang, Endo, Duan, Stoll, Govorov, Sugiyama (2016) A light-driven three-dimensional plasmonic nanosystem that translates molecular motion into reversible chiroptical function http://doi.org/10.1038/ncomms10591
JK Kiviaho, V Linko, A Ora, T Tiainen, E Järvihaavisto, et al. (2016) Cationic polymers for DNA origami coating–examining their binding efficiency and tuning the enzymatic reaction rates, Nanoscale
V Linko, B Shen, K Tapio, JJ Toppari, MA Kostiainen, et al. (2015) One-step large-scale deposition of salt-free DNA origami nanostructures, Scientific reports
A Shapiro, A Hozeh, O Girshevitz, et al. (2015) Cooperativity-based modeling of heterotypic DNA nanostructure assembly, Nucleic Acids Research
Linko, Tapio, Toppari, Kostiainen, Tuukkanen (2015) One-Step Large-Scale Deposition of Purified and Salt-Free DNA Origami Nanostructures http://doi.org/10.1038/srep15634